Phenotypes associated with this allele

• Allele Symbol: Sell^tm2Tft
• Allele Name: targeted mutation 2, Thomas F Tedder
• Allele ID: MGI:3820621
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sell^tm2Tft/Sell^tm2Tft	involves: 129S1/Sv * 129X1/SvJ	MGI:3820636
ht2	Sell^tm2Tft/Sell^tm2.1Tft	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3820639

Genotype
MGI:3820636

hm1

• Allelic Composition: Sell^tm2Tft/Sell^tm2Tft
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

spleen hyperplasia ( J:142184 )

• the cellularity of the spleen is increased by 60% compared to controls partially due to an increase in the number of T cells

lymph node hypoplasia ( J:142184 )

• peripheral lymph node cellularity is reduced by 36%

hematopoietic system

spleen hyperplasia ( J:142184 )

• the cellularity of the spleen is increased by 60% compared to controls partially due to an increase in the number of T cells

growth/size/body

spleen hyperplasia ( J:142184 )

• the cellularity of the spleen is increased by 60% compared to controls partially due to an increase in the number of T cells

Genotype
MGI:3820639

ht2

• Allelic Composition: Sell^tm2Tft/Sell^tm2.1Tft
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

immune system

abnormal leukocyte migration ( J:142184 )

• migration of mutant lymphocytes into lymph nodes and peyer's patches one hour after transfer into wild-type hosts is reduced by 36-37% compared to controls

• activated Vbeta8 T cells have a 4-fold higher migration to peripheral lymph nodes than controls 90 minutes after transfer to wild-type hosts

• leukocyte migration into cremaster tissue is inhibited after exposure to keratonocyte-derived cytokine

impaired leukocyte tethering or rolling ( J:142184 )

• lymphocytes have a lower rolling capacity with a cell flux that is two-thirds of wild-type controls

• the velocity of rolling lymphocytes is a third higher than that found in controls

• splenocytes have only about a fifth the capacity to attach to high endothelial venules as do controls

• rolling velocities in vivo trend higher for leukocytes following infusion with keratinocyte-derived cytokine

abnormal regulatory T cell number ( J:141931 )

• total T regulatory T cell numbers in the peripheral lymph nodes is 21% higher than in controls

• total T regulatory T cell numbers in the mesenteric lymph nodes is 28% less than in controls and 19% less than in the spleen

abnormal neutrophil physiology ( J:142184 )

• there are increased neutrophil counts in peritoneal lavage samples isolated 24 hr after thioglycollate-induced peritonitis

abnormal regulatory T cell physiology ( J:141931 )

• migration of T regulatory cells to peripheral and mesenteric lymph nodes is slightly enhanced compared to wild-type controls

homeostasis/metabolism

abnormal circulating protein level ( J:142184 )

• circulating levels of L-selectin are 40% of those found in controls, and consist of the full-length protein instead of the truncated form that makes up the majority of serum protein in wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:142184 )

• migration of mutant lymphocytes into lymph nodes and peyer's patches one hour after transfer into wild-type hosts is reduced by 36-37% compared to controls

• activated Vbeta8 T cells have a 4-fold higher migration to peripheral lymph nodes than controls 90 minutes after transfer to wild-type hosts

• leukocyte migration into cremaster tissue is inhibited after exposure to keratonocyte-derived cytokine

impaired leukocyte tethering or rolling ( J:142184 )

• lymphocytes have a lower rolling capacity with a cell flux that is two-thirds of wild-type controls

• the velocity of rolling lymphocytes is a third higher than that found in controls

• splenocytes have only about a fifth the capacity to attach to high endothelial venules as do controls

• rolling velocities in vivo trend higher for leukocytes following infusion with keratinocyte-derived cytokine

abnormal regulatory T cell number ( J:141931 )

• total T regulatory T cell numbers in the peripheral lymph nodes is 21% higher than in controls

• total T regulatory T cell numbers in the mesenteric lymph nodes is 28% less than in controls and 19% less than in the spleen

abnormal neutrophil physiology ( J:142184 )

• there are increased neutrophil counts in peritoneal lavage samples isolated 24 hr after thioglycollate-induced peritonitis

abnormal regulatory T cell physiology ( J:141931 )

• migration of T regulatory cells to peripheral and mesenteric lymph nodes is slightly enhanced compared to wild-type controls

cellular

abnormal leukocyte migration ( J:142184 )

• migration of mutant lymphocytes into lymph nodes and peyer's patches one hour after transfer into wild-type hosts is reduced by 36-37% compared to controls

• activated Vbeta8 T cells have a 4-fold higher migration to peripheral lymph nodes than controls 90 minutes after transfer to wild-type hosts

• leukocyte migration into cremaster tissue is inhibited after exposure to keratonocyte-derived cytokine

impaired leukocyte tethering or rolling ( J:142184 )

• lymphocytes have a lower rolling capacity with a cell flux that is two-thirds of wild-type controls

• the velocity of rolling lymphocytes is a third higher than that found in controls

• splenocytes have only about a fifth the capacity to attach to high endothelial venules as do controls

• rolling velocities in vivo trend higher for leukocytes following infusion with keratinocyte-derived cytokine