Analysis Tools
normal phenotype
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• mice are indistinguishable from wild-type mice
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Allele Symbol Allele Name Allele ID |
Nfatc3tm1Grc targeted mutation 1, Gerald R Crabtree MGI:3820410 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells
• however, the rate of apoptosis in vitro is normal
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• the total number of thymocytes is reduced by half of wild-type
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• the total number of thymocytes is reduced by half of wild-type
• the number of single positive T cells in the thymus is lower than in wild-type mice
• however, the number of double positive cells is normal
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• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice
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• mice exhibit an increase in double negative T cell compared to in wild-type mice up to stage DN4
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• in the thymus
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• in the thymus
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• the total number of inguinal lymph node cells is decreased by half of wild-type
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• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells
• however, the rate of apoptosis in vitro is normal
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• the total number of thymocytes is reduced by half of wild-type
|
|
• the total number of thymocytes is reduced by half of wild-type
• the number of single positive T cells in the thymus is lower than in wild-type mice
• however, the number of double positive cells is normal
|
|
• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice
|
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• mice exhibit an increase in double negative T cell compared to in wild-type mice up to stage DN4
|
|
• in the thymus
|
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• in the thymus
|
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• in culture, the initial number of double positive T cell undergoing apoptosis is greater than for wild-type cells
• however, the rate of apoptosis in vitro is normal
|
|
• the total number of thymocytes is reduced by half of wild-type
|
|
• the total number of thymocytes is reduced by half of wild-type
• the number of single positive T cells in the thymus is lower than in wild-type mice
• however, the number of double positive cells is normal
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
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• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice but is not more severe than in Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
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• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice
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• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
|
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• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice but is not more severe than in Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
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• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice
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• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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