Phenotypes associated with this allele

• Allele Symbol: Ildr2^W87*
• Allele Name: amber stop mutation, Ingenium Pharmaceuticals
• Allele ID: MGI:3820395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ildr2^W87*/Ildr2^W87*	involves: C3HeB/FeJ	MGI:3820398

Genotype
MGI:3820398

hm1

• Allelic Composition: Ildr2^W87*/Ildr2^W87*
• Genetic Background: involves: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell differentiation ( J:138216 )

• replication rate is reduced at 14 days of age

decreased pancreatic beta cell mass ( J:138216 )

• significantly decreased at 150 days of age

decreased pancreatic beta cell number ( J:138216 )

• numbers are half those of controls at 14 days of age

homeostasis/metabolism

decreased circulating insulin level ( J:138216 )

• plasma insulin levels are reduced at sexual maturity

impaired glucose tolerance ( J:138216 )

• increased glucose detected when tested at 50 days

cellular

abnormal pancreatic beta cell differentiation ( J:138216 )

• replication rate is reduced at 14 days of age