Phenotypes associated with this allele

• Allele Symbol: Txnip^tm1Rlee
• Allele Name: targeted mutation 1, Richard T Lee
• Allele ID: MGI:3818743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Txnip^tm1Rlee/Txnip^tm1Rlee A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: 129S4/SvJae * FVB/N	MGI:3818746

Genotype
MGI:3818746

cn1

• Allelic Composition: Txnip^tm1Rlee/Txnip^tm1Rlee; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased cardiac muscle cell glucose uptake ( J:141487 )

• robust increase in glucose uptake in 4-hydroxytamoxifen treated mice compared to controls

abnormal response of heart to induced stress ( J:141487 )

• mice treated with 4-hydroxytamoxifen to induce recombination display a decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls

muscle

increased cardiac muscle cell glucose uptake ( J:141487 )

• robust increase in glucose uptake in 4-hydroxytamoxifen treated mice compared to controls

homeostasis/metabolism

abnormal response of heart to induced stress ( J:141487 )

• mice treated with 4-hydroxytamoxifen to induce recombination display a decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls

cellular

increased cardiac muscle cell glucose uptake ( J:141487 )

• robust increase in glucose uptake in 4-hydroxytamoxifen treated mice compared to controls