Phenotypes associated with this allele

• Allele Symbol: Mcm2^{tm1(cre/ERT2)Scpr}
• Allele Name: targeted mutation 1, Steven C Pruitt
• Allele ID: MGI:3818719
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm2^tm1(cre/ERT2)Scpr/Mcm2^tm1(cre/ERT2)Scpr	involves: 129S6/SvEvTac	MGI:3818762

Genotype
MGI:3818762

hm1

• Allelic Composition: Mcm2^{tm1(cre/ERT2)Scpr}/Mcm2^{tm1(cre/ERT2)Scpr}
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:141493 )

• develop normally to adulthood

• become moribund starting at 9 weeks of age

• few survive beyond 12 weeks

• maximum survival 21 weeks

behavior/neurological

hunched posture ( J:141493 )

• exhibited by moribund animals

decreased locomotor activity ( J:141493 )

• exhibited by moribund animals

respiratory system

abnormal breathing pattern ( J:141493 )

• rapid, shallow breathing

• precedes death by 2-3 weeks

muscle

muscle weakness ( J:141493 )

• generalized muscle weakness exhibited by moribund animals

• reduced numbers of myogenic cells in the tibialis anterior muscle

adipose tissue

decreased total body fat amount ( J:141493 )

• exhibited by moribund animals

neoplasm

increased thymoma incidence ( J:141493 )

• most animals develop thymomas

• filling the thoracic cavity

immune system

enlarged spleen ( J:141493 )

• in many animals

hematopoietic system

enlarged spleen ( J:141493 )

• in many animals

abnormal erythrocyte morphology ( J:141493 )

• 2.5 fold increase in the number of micronuclei in peripheral blood erythrocytes

nervous system

abnormal postnatal subventricular zone morphology ( J:141493 )

• density of nuclei is substantially reduced

• reduced neurogenesis

digestive/alimentary system

abnormal small intestine crypts of Lieberkuhn morphology ( J:141493 )

• morphology is disorganized relative to controls

abnormal small intestinal villus morphology ( J:141493 )

• morphology is disorganized relative to controls

intestine polyps ( J:141493 )

• sometimes develop polyps in the small intestine and colon

colon polyps ( J:141493 )

cellular

abnormal cell nucleus morphology ( J:141493 )

• higher frequency of double stranded DNA breaks

abnormal cell cycle ( J:141493 )

• only about 1/3 as many cells in the subventricular zone of the brain actively in the cell cycle relative to controls

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:141493 )

• morphology is disorganized relative to controls

pigmentation

abnormal coat/hair pigmentation ( J:141493 )

• slight graying sometimes observed in moribund animals

integument

abnormal coat/hair pigmentation ( J:141493 )

• slight graying sometimes observed in moribund animals

sparse hair ( J:141493 )

• modest hair loss exhibited by moribund animals

growth/size/body

enlarged spleen ( J:141493 )

• in many animals