Phenotypes associated with this allele

• Allele Symbol: Runx3^tm1Litt
• Allele Name: targeted mutation 1, Dan R Littman
• Allele ID: MGI:3818488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Runx3^tm1Litt/Runx3^tm1Litt	involves: 129P2/OlaHsd	MGI:3821704

Genotype
MGI:3821704

hm1

• Allelic Composition: Runx3^tm1Litt/Runx3^tm1Litt
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )

• peripheral CD8⁺ T cells also express variable amounts of CD4

• 1.6% of CD8⁺ T cells co-express CD103 compared to 12% in controls

abnormal double-positive T cell morphology ( J:141144 )

• peripheral CD8⁺ T cells also express variable amounts of CD4

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )

• peripheral CD8⁺ T cells also express variable amounts of CD4

• 1.6% of CD8⁺ T cells co-express CD103 compared to 12% in controls

abnormal double-positive T cell morphology ( J:141144 )

• peripheral CD8⁺ T cells also express variable amounts of CD4