All Phenotypes Scnm1<tm1.1Mm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scnm1^tm1.1Mm
targeted mutation 1.1, Miriam Meisler
MGI:3818043

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm	involves: 129S6/SvEvTac * C57BL/6 * FVB * SJL	MGI:3818065
hm2	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm	involves: C3HeB/FeJ * C57BL/6 * FVB * SJL	MGI:3818066
hm3	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm	involves: C57BL/6 * C57BL/6J * FVB * SJL	MGI:3818064
cx4	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm Tg(EIIa-cre)C5379Lmgd/0	involves: C57BL/6 * C57BL/6J * FVB * SJL	MGI:3818063
cx5	Scn8a^med-J/Scn8a^med-J Scnm1^tm1.1Mm/Scnm1^tm1.1Mm	involves: C57BL/6 * FVB * SJL * STOCK Krt71^Ca	MGI:3818067

Allelic Composition	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scnm1^tm1.1Mm mutation (0 available); any Scnm1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:141236 )

• mice exhibit no abnormal phenotype

Allelic Composition	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm
Genetic Background	involves: C3HeB/FeJ * C57BL/6 * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scnm1^tm1.1Mm mutation (0 available); any Scnm1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:141236 )

• mice exhibit no abnormal phenotype

Allelic Composition	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm
Genetic Background	involves: C57BL/6 * C57BL/6J * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scnm1^tm1.1Mm mutation (0 available); any Scnm1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:141236 )

N	• mice are viable

normal phenotype

no abnormal phenotype detected ( J:141236 )

• mice exhibit no abnormal phenotype

growth/size/body

growth/size/body region phenotype ( J:141236 )

N	• once the cre transgene is bred out, mice exhibit normal body weights

behavior/neurological

behavior/neurological phenotype ( J:141236 )

N	• mice exhibit normal grip strength and beam walking ability

reproductive system

reproductive system phenotype ( J:141236 )

N	• mice are fertile

Allelic Composition	Scnm1^tm1.1Mm/Scnm1^tm1.1Mm Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: C57BL/6 * C57BL/6J * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scnm1^tm1.1Mm mutation (0 available); any Scnm1 mutation (17 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:141236 )

• mice weigh 50% of wild-type

Allelic Composition	Scn8a^med-J/Scn8a^med-J Scnm1^tm1.1Mm/Scnm1^tm1.1Mm
Genetic Background	involves: C57BL/6 * FVB * SJL * STOCK Krt71^Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^med-J mutation (2 available); any Scn8a mutation (99 available)
Scnm1^tm1.1Mm mutation (0 available); any Scnm1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:141236 )

behavior/neurological

hindlimb paralysis ( J:141236 )

• in all mice

cellular

abnormal cell physiology ( J:141236 )

• mice exhibit reduced splicing of the Scn8a^med-J transcript compared to in wild-type mice and Scn8a^med-J Scnm1^s double homozygotes

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