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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atoh7tm2(Neurod4)Whk
targeted mutation 2, William H Klein
MGI:3817876
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk involves: 129S6/SvEvTac * C57BL/6 MGI:3817913
ht2
 		Atoh7tm1Gan/Atoh7tm2(Neurod4)Whk involves: 129S6/SvEvTac * C57BL/6 MGI:3817914


Genotype
MGI:3817913
ht1
Allelic
Composition		 Atoh7tm1(Neurod1)Whk/Atoh7tm2(Neurod4)Whk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1(Neurod1)Whk mutation (0 available); any Atoh7 mutation (9 available)
Atoh7tm2(Neurod4)Whk mutation (0 available); any Atoh7 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:141248 )
N
• mice exhibit normal numbers of bipolar, Muller glial and amacrine cells
increased retina apoptosis ( J:141248 )
• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice
increased retina photoreceptor cell number ( J:141248 )
• the number of opsin+ photoreceptors is increased by 20% compared to in wild-type mice
abnormal optic nerve morphology ( J:141248 )
• at P30 to P40, one-third of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7tm1Gan homozygotes with the majority correctly orientated towards the optic disk
optic nerve hypoplasia ( J:141248 )
• mice exhibit severe optic nerve hypoplasia
• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

nervous system
increased retina photoreceptor cell number ( J:141248 )
• the number of opsin+ photoreceptors is increased by 20% compared to in wild-type mice
abnormal optic nerve morphology ( J:141248 )
• at P30 to P40, one-third of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7tm1Gan homozygotes with the majority correctly orientated towards the optic disk
optic nerve hypoplasia ( J:141248 )
• mice exhibit severe optic nerve hypoplasia
• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

cellular
increased retina apoptosis ( J:141248 )
• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice




Genotype
MGI:3817914
ht2
Allelic
Composition		 Atoh7tm1Gan/Atoh7tm2(Neurod4)Whk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1Gan mutation (0 available); any Atoh7 mutation (9 available)
Atoh7tm2(Neurod4)Whk mutation (0 available); any Atoh7 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased retina ganglion cell number ( J:141248 )
• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 10% of wild-type but increases by E14.5 likely due to delayed RGC differentiation

nervous system
decreased retina ganglion cell number ( J:141248 )
• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 10% of wild-type but increases by E14.5 likely due to delayed RGC differentiation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory