Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Zbtb7b)C8Rbo mutation
(0 available)
Themistm1Lov mutation
(0 available);
any
Themis mutation
(55 available)
|
|
|
immune system
|
|
• CD8 single positive thymocytes fail to develop in these mice
• transgene expression fails to alleviate the partial block in CD4 development
|
hematopoietic system
|
|
• CD8 single positive thymocytes fail to develop in these mice
• transgene expression fails to alleviate the partial block in CD4 development
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Zbtb7b)C8Rbo mutation
(0 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation
(3 available)
|
|
|
immune system
|
|
• female mice have substantial numbers of HY-specific CD4+ T cells while having a complete absence of HY-specific CD8+ T cells, which is a reversal of the T cell populations that normally develop in female mice carrying just the Tg(TcraH-Y,TcrbH-Y)71Vbo allele
|
hematopoietic system
|
|
• female mice have substantial numbers of HY-specific CD4+ T cells while having a complete absence of HY-specific CD8+ T cells, which is a reversal of the T cell populations that normally develop in female mice carrying just the Tg(TcraH-Y,TcrbH-Y)71Vbo allele
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Zbtb7b)C8Rbo mutation
(0 available)
Tg(TcrLCMV)327Sdz mutation
(8 available)
|
|
|
immune system
|
|
• mice have substantial numbers of transgenic CD4+ T cells while having a complete absence of transgenic CD8+ T cells, which is a reversal of the T cell populations that normally develop in mice carrying just the Tg(TcrLCMV)327Sdz allele
• the CD4 T cells bear high levels of the transgenic TCR, express CD154 upon activation, and have other hallmarks (lack perforin and IFN-gamma expression) of truly belonging to the CD4 lineage and not the CD8 lineage
|
hematopoietic system
|
|
• mice have substantial numbers of transgenic CD4+ T cells while having a complete absence of transgenic CD8+ T cells, which is a reversal of the T cell populations that normally develop in mice carrying just the Tg(TcrLCMV)327Sdz allele
• the CD4 T cells bear high levels of the transgenic TCR, express CD154 upon activation, and have other hallmarks (lack perforin and IFN-gamma expression) of truly belonging to the CD4 lineage and not the CD8 lineage
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
immune system
|
|
• CD4 T cell numbers are almost doubled in the spleen
|
|
|
• CD8 T cells are virtually absent in the periphery (less than 1% of controls)
• single positive CD8+ TCRhi thymocytes are also less than 1% of controls
|
hematopoietic system
|
|
• CD4 T cell numbers are almost doubled in the spleen
|
|
|
• CD8 T cells are virtually absent in the periphery (less than 1% of controls)
• single positive CD8+ TCRhi thymocytes are also less than 1% of controls
|
Analysis Tools