All Phenotypes Zbtb7b<tm2Itan> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Zbtb7b^tm2Itan/Zbtb7b⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7b^tm2Itan mutation (0 available); any Zbtb7b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:141142 )

• while there was a decrease in GFP expression by thymocytes differentiating into CD4 ⁺ T cells, no phenotypic abnormalities are reported

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

• an unusual double negative T cell population is found in the lymph nodes of these mice

• these double negative T cells all express GFP

• peripheral CD4⁺ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus

• single positive CD8⁺ T cell numbers are increased in the thymus and lymph nodes

• some CD8⁺ T cells express GFP

immune system

• an unusual double negative T cell population is found in the lymph nodes of these mice

• these double negative T cells all express GFP

• peripheral CD4⁺ T cell numbers are reduced by almost two-thirds compared to controls with less dramatic differences in the thymus

• single positive CD8⁺ T cell numbers are increased in the thymus and lymph nodes

• some CD8⁺ T cells express GFP

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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