Phenotypes associated with this allele

• Allele Symbol: Lmna^tm3Lgf
• Allele Name: targeted mutation 3, Loren G Fong
• Allele ID: MGI:3817495
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmna^tm3Lgf/Lmna^tm3Lgf	involves: 129P2/OlaHsd	MGI:4868584
hm2	Lmna^tm3Lgf/Lmna^tm3Lgf	involves: 129P2/OlaHsd * C57BL/6	MGI:3817508
ht3	Lmna^tm3Lgf/Lmna^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3817507

Genotype
MGI:4868584

hm1

• Allelic Composition: Lmna^tm3Lgf/Lmna^tm3Lgf
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:167229 )

skeleton

abnormal axial skeleton morphology ( J:167229 )

rib fractures ( J:167229 )

decreased bone mineral density ( J:167229 )

cellular

abnormal cell nucleus morphology ( J:167229 )

growth/size/body

decreased body weight ( J:167229 )

adipose tissue

decreased total body fat amount ( J:167229 )

Genotype
MGI:3817508

hm2

• Allelic Composition: Lmna^tm3Lgf/Lmna^tm3Lgf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:141165 )

• mice die by 17 weeks of age

skeleton

rib fractures ( J:141165 )

• mice exhibit multiple rib fractures by 12 weeks of age

adipose tissue

decreased subcutaneous adipose tissue amount ( J:141165 )

• at 4 to 8 weeks of age

decreased abdominal adipose tissue amount ( J:141165 )

• at 4 to 8 weeks of age

cellular

abnormal cell nucleus morphology ( J:141165 )

• mouse embryonic fibroblasts exhibit more misshapen nuclei than in wild-type or Lmna^tm1Lgf heterozygotes

growth/size/body

weight loss ( J:141165 )

• mice begin to lose weight at 4 to 8 weeks of age

integument

decreased subcutaneous adipose tissue amount ( J:141165 )

• at 4 to 8 weeks of age

Genotype
MGI:3817507

ht3

• Allelic Composition: Lmna^tm3Lgf/Lmna⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:141165 )

• mice die by 50 weeks of age

skeleton

skeleton phenotype ( J:141165 )

N • mice exhibit normal bone density and cortical thickness in the ribs

rib fractures ( J:141165 )

• mice develop progressive rib fractures near the costovertebral joints as they age that are not as numerous as in Lmna^tm1Lgf heterozygotes at the time of death

kyphosis ( J:141165 )

• mice develop kyphosis that is not as severe as in Lmna^tm1Lgf heterozygotes

adipose tissue

decreased percent body fat/body weight ( J:141165 )

• mice exhibit reduced body fat compared to in wild-type mice but not as severely as in Lmna^tm1Lgf heterozygotes

growth/size/body

decreased body weight ( J:141165 )

• mice exhibit reduced body weight compared to wild-type mice that is not as severe as in Lmna^tm1Lgf heterozygotes