Analysis Tools
mortality/aging
skeleton
cellular
growth/size/body
adipose tissue
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Allele Symbol Allele Name Allele ID |
Lmnatm3Lgf targeted mutation 3, Loren G Fong MGI:3817495 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by 17 weeks of age
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• mice exhibit multiple rib fractures by 12 weeks of age
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• at 4 to 8 weeks of age
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• at 4 to 8 weeks of age
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• mouse embryonic fibroblasts exhibit more misshapen nuclei than in wild-type or Lmnatm1Lgf heterozygotes
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• mice begin to lose weight at 4 to 8 weeks of age
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• at 4 to 8 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by 50 weeks of age
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| N |
• mice exhibit normal bone density and cortical thickness in the ribs
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• mice develop progressive rib fractures near the costovertebral joints as they age that are not as numerous as in Lmnatm1Lgf heterozygotes at the time of death
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• mice exhibit reduced body fat compared to in wild-type mice but not as severely as in Lmnatm1Lgf heterozygotes
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• mice exhibit reduced body weight compared to wild-type mice that is not as severe as in Lmnatm1Lgf heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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