Phenotypes associated with this allele

• Allele Symbol: Piezo1⁺
• Allele Name: wild type
• Allele ID: MGI:3815325
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Piezo1^tm1b(KOMP)Wtsi/Piezo1^+	C57BL/6N-Piezo1^tm1b(KOMP)Wtsi/MbpMmucd	MGI:6325165
ht2	Piezo1^tm1b(KOMP)Wtsi/Piezo1^+	C57BL/6N-Piezo1^tm1b(KOMP)Wtsi/Ucd	MGI:6263160
ht3	Piezo1^em1Dbee/Piezo1^+	C57BL/6-Piezo1^em1Dbee	MGI:8215455
ht4	Piezo1^Gt(RST343)Byg/Piezo1^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5705804
ht5	Piezo1^tm1a(KOMP)Wtsi/Piezo1^+	involves: C57BL/6J * C57BL/6N	MGI:5824009

Genotype
MGI:6325165

ht1

• Allelic Composition: Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺
• Genetic Background: C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/MbpMmucd
• Cell Lines: EPD0500_5_B12

Data Sources

IMPC Data for Piezo1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo size ( J:211773 )

IMPC - TCP

abnormal placenta size ( J:211773 )

IMPC - TCP

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - TCP

Genotype
MGI:6263160

ht2

• Allelic Composition: Piezo1^{tm1b(KOMP)Wtsi}/Piezo1⁺
• Genetic Background: C57BL/6N-Piezo1^{tm1b(KOMP)Wtsi}/Ucd
• Cell Lines: EPD0500_5_B12

Data Sources

IMPC Data for Piezo1

behavior/neurological

decreased locomotor activity ( J:211773 )

♀

IMPC - UCD

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - UCD

renal/urinary system

abnormal urinary bladder morphology ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:8215455

ht3

• Allelic Composition: Piezo1^em1Dbee/Piezo1⁺
• Genetic Background: C57BL/6-Piezo1^em1Dbee

hematopoietic system

abnormal erythrocyte physiology ( J:368272 )

• membrane potential recordings using patch-clamp on RBCs shows that depolarization in response to sheer stress (i.e. fluid flow) tends to be larger in RBCs and there is a failure to recover after flow ceases

• single-channel activity of RBCs measured by the cell-attached patch technique shows higher activity after termination of pressure pulses, with frequency of open-state activity higher relative to the closed-state frequency, indicating persistent activity and failure of deactivation in single channels

decreased erythrocyte osmotic fragility ( J:368272 )

• mice show a decrease in osmotic fragility, but less than in homozygotes

Genotype
MGI:5705804

ht4

• Allelic Composition: Piezo1^{Gt(RST343)Byg}/Piezo1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:212179 )

• heterozygotes are viable and fertile

Genotype
MGI:5824009

ht5

• Allelic Composition: Piezo1^{tm1a(KOMP)Wtsi}/Piezo1⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0500_5_F12

cardiovascular system

abnormal vascular endothelial cell morphology ( J:217082 )

• at 6-8 weeks of age, cerebral arteries show a striking misorganization of CD31-positive endothelial cells with a directionless cobblestone-like appearance, unlike the linear appearance in the direction of flow observed wild-type controls