All Phenotypes Sptlc1<tm1Jia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sptlc1^tm1Jia
targeted mutation 1, Xian-cheng Jiang
MGI:3815115

Summary

2 genotypes

Allelic Composition	Sptlc1^tm1Jia/Sptlc1^tm1Jia
Genetic Background	B6.Cg-Sptlc1^tm1Jia

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptlc1^tm1Jia mutation (0 available); any Sptlc1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• homozygotes die prior to E15-20

Allelic Composition	Sptlc1^tm1Jia/Sptlc1⁺
Genetic Background	B6.Cg-Sptlc1^tm1Jia

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptlc1^tm1Jia mutation (0 available); any Sptlc1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:140627 )

• mice have decreased liver levels of sphingolipids including derivatives of ceramide and sphingosine

• however, mice have normal liver levels sphingosine-1-phosphate

abnormal circulating lipid level ( J:140627 )

• mice have decreased plasma levels of sphingolipids including ceramide and sphingosine-1-phosphate derivatives

• lysosphingomyelin is especially affected with a 16.4 fold reduction in the plasma level

• however, levels of sphingomyelin derivatives are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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