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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cthrc1tm1Hssk
targeted mutation 1, Hiroshi Sasaki
MGI:3815067
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
\Cthrc1tm1Hssk/\Cthrc1tm1Hssk either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1) MGI:3815419
cx2
\Cthrc1tm1Hssk/\Cthrc1+
\Vangl2Lp/\Vangl2+
involves: 129P2/OlaHsd * C57BL/6 MGI:3815075
cx3
\Cthrc1tm1Hssk/\Cthrc1tm1Hssk
\Vangl2Lp/\Vangl2+
involves: 129P2/OlaHsd * C57BL/6 MGI:3815076
cx4
\Cthrc1tm1Hssk/\Cthrc1+
\Vangl2Lp/\Vangl2+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:3815079


Genotype
MGI:3815419
hm1
Allelic
Composition
\Cthrc1tm1Hssk/\Cthrc1tm1Hssk
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Hssk mutation (1 available); any Cthrc1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3815075
cx2
Allelic
Composition
\Cthrc1tm1Hssk/\Cthrc1+
\Vangl2Lp/\Vangl2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Hssk mutation (1 available); any Cthrc1 mutation (34 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Background Sensitivity: defects seen in the midbrain region at E13.5

hearing/vestibular/ear
N
• sensory hair cells in the cochlea are normal

embryo
• Background Sensitivity: defects seen in the midbrain region at E13.5




Genotype
MGI:3815076
cx3
Allelic
Composition
\Cthrc1tm1Hssk/\Cthrc1tm1Hssk
\Vangl2Lp/\Vangl2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Hssk mutation (1 available); any Cthrc1 mutation (34 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• orientation is significantly disrupted
• organization of hair cells is normal
• disruptions are most severe for inner hair cells

nervous system
• orientation is significantly disrupted
• organization of hair cells is normal
• disruptions are most severe for inner hair cells




Genotype
MGI:3815079
cx4
Allelic
Composition
\Cthrc1tm1Hssk/\Cthrc1+
\Vangl2Lp/\Vangl2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Hssk mutation (1 available); any Cthrc1 mutation (34 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• Background Sensitivity: no defects in neural tube closure are seen





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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory