Phenotypes associated with this allele

• Allele Symbol: Tg(CD19)1Tft
• Allele Name: transgene insertion 1, Thomas F Tedder
• Allele ID: MGI:3814908
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CD19)1Tft/Tg(CD19)1Tft	involves: C57BL/6 * C57BL/6J * SJL	MGI:3814929
tg2	Tg(CD19)1Tft/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:3814928

Genotype
MGI:3814929

tg1

• Allelic Composition: Tg(CD19)1Tft/Tg(CD19)1Tft
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM, mice exhibit an increase in B cell proliferation compared to in similarly treated wild-type mice

• the level of B cell spontaneous proliferation is higher than in wild-type mice

decreased B cell number ( J:27236 )

• the frequency of IgM+ B220^hi B cell is reduced 81% compared to in wild-type mice

• the number of B cells is reduced in the blood (95%), spleen (82%), and peritoneum (70%) compared to in wild-type mice

decreased immature B cell number ( J:27236 )

• the frequency of IgM+ B220^lo immature B cells in the blood is decreased 55% compared to in wild-type mice

decreased IgG1 level ( J:27236 )

• levels in unimmunized mice are 39% lower than in wild-type mice

increased IgG2a level ( J:27236 )

• levels in unimmunized mice are 84% higher than in wild-type mice

increased IgG2b level ( J:27236 )

• levels in unimmunized mice are 168% higher than in wild-type mice

decreased IgG3 level ( J:27236 )

• levels in unimmunized mice are 77% lower than in wild-type mice

increased IgM level ( J:27236 )

• levels in unimmunized mice are 20% higher than in wild-type mice

hematopoietic system

increased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM, mice exhibit an increase in B cell proliferation compared to in similarly treated wild-type mice

• the level of B cell spontaneous proliferation is higher than in wild-type mice

decreased B cell number ( J:27236 )

• the frequency of IgM+ B220^hi B cell is reduced 81% compared to in wild-type mice

• the number of B cells is reduced in the blood (95%), spleen (82%), and peritoneum (70%) compared to in wild-type mice

decreased immature B cell number ( J:27236 )

• the frequency of IgM+ B220^lo immature B cells in the blood is decreased 55% compared to in wild-type mice

decreased IgG1 level ( J:27236 )

• levels in unimmunized mice are 39% lower than in wild-type mice

increased IgG2a level ( J:27236 )

• levels in unimmunized mice are 84% higher than in wild-type mice

increased IgG2b level ( J:27236 )

• levels in unimmunized mice are 168% higher than in wild-type mice

decreased IgG3 level ( J:27236 )

• levels in unimmunized mice are 77% lower than in wild-type mice

increased IgM level ( J:27236 )

• levels in unimmunized mice are 20% higher than in wild-type mice

cellular

increased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM, mice exhibit an increase in B cell proliferation compared to in similarly treated wild-type mice

• the level of B cell spontaneous proliferation is higher than in wild-type mice

Genotype
MGI:3814928

tg2

• Allelic Composition: Tg(CD19)1Tft/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

immune system

increased B cell proliferation ( J:27236 )

• following stimulation with LPS, mice exhibit an intermediate increase in B cell proliferation compared to in Tg1Tft homozygotes

decreased B cell number ( J:27236 )

• the frequency of IgM+ B220^hi B cell is reduced compared to in wild-type mice

• the number of B cells is reduced in the blood, and spleen compared to in wild-type mice

hematopoietic system

increased B cell proliferation ( J:27236 )

• following stimulation with LPS, mice exhibit an intermediate increase in B cell proliferation compared to in Tg1Tft homozygotes

decreased B cell number ( J:27236 )

• the frequency of IgM+ B220^hi B cell is reduced compared to in wild-type mice

• the number of B cells is reduced in the blood, and spleen compared to in wild-type mice

cellular

increased B cell proliferation ( J:27236 )

• following stimulation with LPS, mice exhibit an intermediate increase in B cell proliferation compared to in Tg1Tft homozygotes