Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mom mutation
(6 available);
any
Tcra mutation
(97 available)
Tg(TcraAV19AJ33)1Shima mutation
(0 available)
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immune system
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• the only T cells present in the mice express a transgenic alpha chain that is associated with NK T cells
• Valpha 14 NK T cells are not present in these mice
• 30% of mononuclear cells in the liver are transgenic NK T cells
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• the NK T cells are also reactive to alpha-ManCer
• NK T cells respond to alpha-GalCer, a ligand normally associated with Valpha14 NK T cell activation
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hematopoietic system
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• the only T cells present in the mice express a transgenic alpha chain that is associated with NK T cells
• Valpha 14 NK T cells are not present in these mice
• 30% of mononuclear cells in the liver are transgenic NK T cells
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• NK T cells respond to alpha-GalCer, a ligand normally associated with Valpha14 NK T cell activation
• the NK T cells are also reactive to alpha-ManCer
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain
• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time
• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells
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immune system
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• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain
• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time
• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells
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• transgenic NK T cells isolated from these mice induce IL-10 secretion from CD19+ B cells and other NK T cells
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• the progression and development of MOG-induced EAE is suppressed in these mice compared to both wild-type and Cd1d1/Cd1d2tm1Crw homozygotes
• mean severity score is 1.3 versus 3.3 in wild-type controls
• mice at day 15 post induction have 3-fold less infiltrating mononuclear cells in their spinal cord with a lower percentage of CD4+ T cells making up the infiltrate (6% of infiltrating cells vs 21% in littermate controls)
• memory T cells isolated from mice 10 days after disease induction produce less inflammatory cytokines (IFN-g, TNF, IL-2 and IL-17) and more IL-10
• mean day of onset is 14.3 compared to 13.6 for wild-type controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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• the number of total NK T cell numbers are slightly higher with a normal number of Valpha14 NK T cells and slightly higher numbers of Valpha 19 NK T cells
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• NK T cells isolated from the liver secrete more TH-1 and TH-2 cytokines than NK T cells isolated from WT mice
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• the progression and development of MOG-induced EAE is suppressed in these mice
• mean day of onset is 18.6 compared to 13.6 for wild-type controls
• mean severity score is 1.3 versus 3.6 in wild-type controls
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hematopoietic system
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• the number of total NK T cell numbers are slightly higher with a normal number of Valpha14 NK T cells and slightly higher numbers of Valpha 19 NK T cells
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• NK T cells isolated from the liver secrete more TH-1 and TH-2 cytokines than NK T cells isolated from WT mice
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Analysis Tools