Analysis Tools
mortality/aging
|
• no viable embryos were found, no time of lethality was provided
|
|
Allele Symbol Allele Name Allele ID |
Trpm7tm1.1Clph targeted mutation 1.1, David E Clapham MGI:3814706 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no viable embryos were found, no time of lethality was provided
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no viable embryos were found, no time of lethality was provided
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 85% penetrance of thymic abnormalities
• CD3+ T cells are found distributed throughout the thymus
|
|
• increase in the percentage and number of double negative T cells
• increase in the percentage of cells in the DN3 stage
|
|
• the boundary between the cortical and medullary regions is not well defined
|
|
• progressive loss of thymic medullary cells
|
|
• substantial reduction in the number of thymocytes
|
|
• partial block in the transition from double negative to double positive T cells
• block appears to be at the DN3 to DN4 transition as a significant proportion of cells fail to down regulate CD25
|
|
• slight decrease in the percentage and number of T cells in the spleen and lymph nodes but not in the intestine
|
|
• thymocytes lack Mg2+ inhibitable current
• however, Mg2+ influx into freshly isolated T cells is unaffected
|
|
• 85% penetrance of thymic abnormalities
• CD3+ T cells are found distributed throughout the thymus
|
|
• increase in the percentage and number of double negative T cells
• increase in the percentage of cells in the DN3 stage
|
|
• the boundary between the cortical and medullary regions is not well defined
|
|
• progressive loss of thymic medullary cells
|
|
• substantial reduction in the number of thymocytes
|
|
• partial block in the transition from double negative to double positive T cells
• block appears to be at the DN3 to DN4 transition as a significant proportion of cells fail to down regulate CD25
|
|
• slight decrease in the percentage and number of T cells in the spleen and lymph nodes but not in the intestine
|
|
• thymocytes lack Mg2+ inhibitable current
• however, Mg2+ influx into freshly isolated T cells is unaffected
|
|
• 85% penetrance of thymic abnormalities
• CD3+ T cells are found distributed throughout the thymus
|
|
• increase in the percentage and number of double negative T cells
• increase in the percentage of cells in the DN3 stage
|
|
• the boundary between the cortical and medullary regions is not well defined
|
|
• progressive loss of thymic medullary cells
|
|
• substantial reduction in the number of thymocytes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no viable embryos were found, no time of lethality was provided
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||