All Phenotypes Tab1<tm1.1Mis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tab1^tm1.1Mis
targeted mutation 1.1, Yuji Mishina
MGI:3814197

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tab1^tm1.1Mis/Tab1^tm1.1Mis	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3814207
ht2	Tab1^tm1Mis/Tab1^tm1.1Mis	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3814208

Allelic Composition	Tab1^tm1.1Mis/Tab1^tm1.1Mis
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tab1^tm1.1Mis mutation (0 available); any Tab1 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal interventricular septum morphology ( J:140317 )

hemorrhage ( J:140317 )

• at E16.5

respiratory system

abnormal pulmonary alveolus morphology ( J:140317 )

• the alveoli fails to expand as in wild-type mice

homeostasis/metabolism

edema ( J:140317 )

• at E16.5

Allelic Composition	Tab1^tm1Mis/Tab1^tm1.1Mis
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tab1^tm1.1Mis mutation (0 available); any Tab1 mutation (93 available)
Tab1^tm1Mis mutation (0 available); any Tab1 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:140317 )

• though born in Mendelian ratios, mice do not survive to weaning

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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