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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dcaf1tm1.2Yxi
targeted mutation 1.2, Yue Xiong
MGI:3814063
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dcaf1tm1.2Yxi/Dcaf1tm1.2Yxi involves: C57BL/6 MGI:3814065
cn2
 		Dcaf1tm1.1Yxi/Dcaf1tm1.2Yxi involves: 129P2/OlaHsd * C57BL/6 MGI:3814066


Genotype
MGI:3814065
hm1
Allelic
Composition		 Dcaf1tm1.2Yxi/Dcaf1tm1.2Yxi
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcaf1tm1.2Yxi mutation (0 available); any Dcaf1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3814066
cn2
Allelic
Composition		 Dcaf1tm1.1Yxi/Dcaf1tm1.2Yxi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcaf1tm1.1Yxi mutation (1 available); any Dcaf1 mutation (69 available)
Dcaf1tm1.2Yxi mutation (0 available); any Dcaf1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:140246 )
• 96 hours after transduction of viral cre there is a substantial decrease in the S-phase cell population in MEFs
increased fibroblast apoptosis ( J:140246 )
• following transduction of viral cre there is a substantial increase in apoptosis in MEFs
decreased fibroblast proliferation ( J:140246 )
• following transduction of viral cre proliferation decreases by nearly 60% in MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory