Phenotypes associated with this allele

• Allele Symbol: Tnfrsf19^{Gt(OST294987)Lex}
• Allele Name: gene trap OST294987, Lexicon Genetics
• Allele ID: MGI:3813972
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf19^Gt(OST294987)Lex/Tnfrsf19^Gt(OST294987)Lex	involves: 129S5/SvEvBrd	MGI:3818298
cx2	Eda^Ta/Eda^Ta Tnfrsf19^Gt(OST294987)Lex/Tnfrsf19^Gt(OST294987)Lex	involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe	MGI:3818299
cx3	Eda^Ta/Y Tnfrsf19^Gt(OST294987)Lex/Tnfrsf19^Gt(OST294987)Lex	involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe	MGI:3818300

Genotype
MGI:3818298

hm1

• Allelic Composition: Tnfrsf19^{Gt(OST294987)Lex}/Tnfrsf19^{Gt(OST294987)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

impaired blood-brain barrier function ( J:181470 )

• modest impairment

reproductive system

reproductive system phenotype ( J:140329 )

N • mice are fertile with normal nursing behavior, normal numbers of nipples and normal mammary gland development

craniofacial

craniofacial phenotype ( J:140329 )

N • mice exhibit normal tooth number and shape

integument

integument phenotype ( J:140329 )

N • mice exhibit normal skin and hair with normal sweating ability

nervous system

impaired blood-brain barrier function ( J:181470 )

• modest impairment

Genotype
MGI:3818299

cx2

• Allelic Composition: Eda^Ta/Eda^Ta; Tnfrsf19^{Gt(OST294987)Lex}/Tnfrsf19^{Gt(OST294987)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

craniofacial

abnormal tooth morphology ( J:140329 )

♀ • mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

♀ • some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

♀ • molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

♀ • some mice exhibit a loss of the third molar

skeleton

abnormal tooth morphology ( J:140329 )

♀ • mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

♀ • some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

♀ • molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

♀ • some mice exhibit a loss of the third molar

endocrine/exocrine glands

absent sweat gland ( J:140329 )

♀ • mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

♀ • mice produce no sweat

integument

absent sweat gland ( J:140329 )

♀ • mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

♀ • mice produce no sweat

abnormal coat/ hair morphology ( J:140329 )

♀ • mice possess only awl hairs

absent auchene hairs ( J:140329 )

♀

abnormal awl hair morphology ( J:140329 )

♀

alopecia ( J:140329 )

♀ • mice exhibit a bald patch at the top of the vertex that is expanded in some mice into the neck and extends laterally in a symmetrical pattern

♀ • alopecia is evident at the time of first hair emergence and not associated with sex, age or hair cycling

delayed hair appearance ( J:140329 )

♀ • compared to in Eda^Ta homozygotes

absent guard hair ( J:140329 )

♀

absent zigzag hairs ( J:140329 )

♀

abnormal hair follicle development ( J:140329 )

♀ • mice lack primary and secondary hair follicles

♀ • however, treatment with Eda-A1 restores secondary hair follicles

♀ • at E18, follicle development in the center of the cranium is absent

growth/size/body

abnormal tooth morphology ( J:140329 )

♀ • mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

♀ • some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

♀ • molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

♀ • some mice exhibit a loss of the third molar

Genotype
MGI:3818300

cx3

• Allelic Composition: Eda^Ta/Y; Tnfrsf19^{Gt(OST294987)Lex}/Tnfrsf19^{Gt(OST294987)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

craniofacial

abnormal tooth morphology ( J:140329 )

♂ • mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

♂ • some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

♂ • molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

♂ • some mice exhibit a loss of the third molar

skeleton

abnormal tooth morphology ( J:140329 )

♂ • mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

♂ • some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

♂ • molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

♂ • some mice exhibit a loss of the third molar

endocrine/exocrine glands

absent sweat gland ( J:140329 )

♂ • mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

♂ • mice produce no sweat

integument

absent sweat gland ( J:140329 )

♂ • mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

♂ • mice produce no sweat

abnormal coat/ hair morphology ( J:140329 )

♂ • mice possess only awl hairs

absent auchene hairs ( J:140329 )

♂

abnormal awl hair morphology ( J:140329 )

♂

alopecia ( J:140329 )

♂ • mice exhibit a bald patch at the top of the vertex that is expanded in some mice into the neck and extends laterally in a symmetrical pattern

♂ • alopecia is evident at the time of first hair emergence and not associated with sex, age or hair cycling

delayed hair appearance ( J:140329 )

♂ • compared to in Eda^Ta homozygotes

absent guard hair ( J:140329 )

♂

absent zigzag hairs ( J:140329 )

♂

abnormal hair follicle development ( J:140329 )

♂ • mice lack primary and secondary hair follicles

♂ • at E18, follicle development in the center of the cranium is absent

♂ • however, treatment with Eda-A1 restores secondary hair follicles

growth/size/body

abnormal tooth morphology ( J:140329 )

♂ • mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

♂ • some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

♂ • molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

♂ • some mice exhibit a loss of the third molar