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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tet2Gt(Ayu17-449)Imeg
gene trap Ayu17-449, Institute of Molecular Embryology and Genetics
MGI:3813933
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tet2Gt(Ayu17-449)Imeg/Tet2Gt(Ayu17-449)Imeg involves: C57BL/6 * CBA MGI:3813935


Genotype
MGI:3813935
hm1
Allelic
Composition		 Tet2Gt(Ayu17-449)Imeg/Tet2Gt(Ayu17-449)Imeg
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet2Gt(Ayu17-449)Imeg mutation (0 available); any Tet2 mutation (782 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:140275 )
• 95% mice are dead by P1
postnatal lethality ( J:140275 )
• all mice are dead by P2

renal/urinary system
abnormal proximal convoluted tubule morphology ( J:140275 )
• mice exhibit a loss of acidic granules from the proximal convoluted tubules of the kidney




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory