Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cat,-TBX3)1Vmc mutation
(0 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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cardiovascular system
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• mice exhibit hypoplastic chamber walls with reduced cellular proliferation in the ventricular walls compared to in control mice
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• mice exhibit a subendocardial space near the atrioventricular cushions filled with mesenchymal cells unlike in control mice
• mice exhibit abnormal cardiac jelly and cushion formation in chamber myocardium compared with control mice
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muscle
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• mice exhibit hypoplastic chamber walls with reduced cellular proliferation in the ventricular walls compared to in control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• 90% of intact right and 40% of intact left atria free from sinoatrial node and internodal tract myocytes show ectopic spontaneous electrical activity indicating ectopic pacemaker activity
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• examination of RR intervals reveals short periods of 1 - 3 irregular, premature beats between periods of normal activity
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• develop dilation of the atria several weeks after birth
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• develop atrial fibrosis several weeks after birth
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• 7 of 15 isolated right atrial myocytes showed pacemaker activity which was not seen in any myocytes from controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• at E17.5, mice exhibit a thick sub-endocardial layer of cells in the atria unlike in control mice
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Analysis Tools