Phenotypes associated with this allele

• Allele Symbol: Reg2^tm1Lchr
• Allele Name: targeted mutation 1, Laurence Christa
• Allele ID: MGI:3812476
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Reg2^tm1Lchr/Reg2^tm1Lchr	involves: 129P2/OlaHsd * C57BL/6	MGI:3812507

Genotype
MGI:3812507

hm1

• Allelic Composition: Reg2^tm1Lchr/Reg2^tm1Lchr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:140235 )

• following treatment with J0-2 to induce fulminant hepatitis, fewer mice survive than in similarly treated wild-type mice

• following partial hepatectomy, mice exhibit increased mortality compared to similarly treated wild-type mice

liver/biliary system

decreased hepatocyte proliferation ( J:140235 )

• following two thirds partial hepatectomy, hepatocytes exhibit reduced proliferation associated with extended S phase and fewer mitotic cells compared to in wild-type cells

delayed liver regeneration ( J:140235 )

• following partial hepatectomy, mice exhibit increased mortality and delayed liver mass restoration compared to similarly treated wild-type mice

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:140023 )

• following facial nerve lesion, mice fail to exhibit rescue of nerve loss when treated with ciliary neurotrophic factor unlike wild-type mice

increased susceptibility to injury ( J:140235 )

• mice are more susceptible to fulminant hepatitis induced by J0-2 than wild-type mice as indicated by decreased survival, increased serum levels of alanine transaminase and aspartate transaminase and increased apoptosis

nervous system

nervous system phenotype ( J:140023 )

N • mice exhibit normal motor neurons

abnormal hypoglossal nerve morphology ( J:140023 )

• at P5, myelination of the hypoglossal nerve is delayed compared to in wild-type mice

• however, myelination of the hypoglossal nerve is normal by P21

behavior/neurological

abnormal suckling behavior ( J:140023 )

• mice exhibit impaired suckling behavior compared to wild-type mice

cellular

increased cellular sensitivity to oxidative stress ( J:140235 )

• following partial hepatectomy, mice exhibit increased sensitivity to Fas induced oxidative stress compared to similarly treated wild-type mice

decreased hepatocyte proliferation ( J:140235 )

• following two thirds partial hepatectomy, hepatocytes exhibit reduced proliferation associated with extended S phase and fewer mitotic cells compared to in wild-type cells