Phenotypes associated with this allele

• Allele Symbol: Gabra2^tm1Dns
• Allele Name: targeted mutation 1, D N Stephens
• Allele ID: MGI:3812421
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra2^tm1Dns/Gabra2^tm1Dns	involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6J	MGI:3812433

Genotype
MGI:3812433

hm1

• Allelic Composition: Gabra2^tm1Dns/Gabra2^tm1Dns
• Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:140077 )

• 30% of mice do not survive to weaning

postnatal lethality ( J:140077 )

• 30% of mice do not survive to weaning

behavior/neurological

abnormal conditioned emotional response ( J:140077 )

• mice exhibit a greater suppression in response to conditioned stimulus presentation paired with footshock compared to similarly treated wild-type mice

• administration of phentobarbital or diazepam did not affect response to condition stimuli presentation unlike in wild-type mice that exhibit an increase in suppression ratio