Phenotypes associated with this allele

• Allele Symbol: Ccrl2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3812407
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccrl2^tm1Lex/Ccrl2^tm1Lex	involves: 129S/SvEvBrd * C57BL/6	MGI:3812408

Genotype
MGI:3812408

hm1

• Allelic Composition: Ccrl2^tm1Lex/Ccrl2^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:140110 )

• following sensitizing dose of DNP-IgE at 50 ng per ear, mice exhibit an impaired passive cutaneous anaphylaxis response compared to wild-type mice

• however, mice exhibit a normal passive cutaneous anaphylaxis response at higher sensitizing doses of DNP-specific IgE

• when cells are engrafted into Kit^W-sh mice and sensitized with 5 ng DNP-specific IgE, mice exhibit an impaired passive cutaneous anaphylaxis response with 50% fewer leukocytes at the site compared to when wild-type cells are engrafted