Phenotypes associated with this allele

• Allele Symbol: Ooep^{Gt(139A2)Cmhd}
• Allele Name: gene trap 139A2, Centre for Modeling Human Disease
• Allele ID: MGI:3812181
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ooep^Gt(139A2)Cmhd/Ooep^Gt(139A2)Cmhd	involves: 129S1/Sv * 129X1/SvJ	MGI:3812187
cx2	Nlrp5^tm1Zbt/Nlrp5^tm1Zbt Ooep^Gt(139A2)Cmhd/Ooep^Gt(139A2)Cmhd	involves: 129S1/Sv * 129X1/SvJ	MGI:3812188
cx3	Nlrp5^tm1Zbt/Nlrp5^tm1Zbt Ooep^Gt(139A2)Cmhd/Ooep^Gt(139A2)Cmhd Tle6^tm1Lil/Tle6^tm1Lil	involves: 129S1/Sv * 129X1/SvJ	MGI:6403125

Genotype
MGI:3812187

hm1

• Allelic Composition: Ooep^{Gt(139A2)Cmhd}/Ooep^{Gt(139A2)Cmhd}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal microtubule cytoskeleton morphology ( J:276268 )

• zygotes lack a fine meshwork of cytoplasmic F-actin resulting in acentric spindle position

maternal effect ( J:140105 )

reproductive system

reproductive system phenotype ( J:140105 )

N • despite failure to produce offspring, females release a normal number of eggs when super-ovulated and eggs can be fertilized

female infertility ( J:140105 )

♀

embryo

abnormal embryo development ( J:140105 )

• fewer than 2% of embryos from homozygous females progress beyond the 2 cell stage

Genotype
MGI:3812188

cx2

• Allelic Composition: Nlrp5^tm1Zbt/Nlrp5^tm1Zbt; Ooep^{Gt(139A2)Cmhd}/Ooep^{Gt(139A2)Cmhd}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

reproductive system

female infertility ( J:140105 )

♀

embryo

abnormal embryo development ( J:140105 )

• fewer than 2% of embryos from homozygous females progress beyond the 2 cell stage

cellular

maternal effect ( J:140105 )

Genotype
MGI:6403125

cx3

• Allelic Composition: Nlrp5^tm1Zbt/Nlrp5^tm1Zbt; Ooep^{Gt(139A2)Cmhd}/Ooep^{Gt(139A2)Cmhd}; Tle6^tm1Lil/Tle6^tm1Lil
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

cellular

abnormal mitotic spindle morphology ( J:276268 )

• zygotes exhibit mitotic spindle that are dysmorphic, smaller and displaced from the cell center

embryo

failure of zygotic cell division ( J:276268 )

• asymmetric division