Phenotypes associated with this allele

• Allele Symbol: Tg(Cryaa-cre,Tyr)39Mlr
• Allele Name: transgene insertion 39, Mike Robinson
• Allele ID: MGI:3811526
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Tg(Cryaa-cre,Tyr)39Mlr/?	involves: 129P2/OlaHsd * FVB/N	MGI:3811550
cn2	Dlg1^tm1.1Agri/Dlg1^tm1.1Agri Tg(Cryaa-cre,Tyr)39Mlr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:4354994

Genotype
MGI:3811550

cn1

• Allelic Composition: Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm; Tg(Cryaa-cre,Tyr)39Mlr/?
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

nuclear cataract ( J:139969 )

• mice are pre-disposed to developing nuclear cataracts as they age but otherwise have a normal eye phenotype

Genotype
MGI:4354994

cn2

• Allelic Composition: Dlg1^tm1.1Agri/Dlg1^tm1.1Agri; Tg(Cryaa-cre,Tyr)39Mlr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

vision/eye

increased lens fiber apoptosis ( J:151538 )

• in the anterior, posterior, and center of the lens

abnormal lens morphology ( J:151538 )

• lenses exhibit an abnormal shape with shortened anterior-posterior dimension

abnormal lens development ( J:151538 )

• denucleation of the fiber cell compartment is delayed compared to in wild-type mice

• anterior and posterior suture formation is defective

• differentiation of fiber cells is disrupted

abnormal lens fiber morphology ( J:151538 )

• in some mice fiber cells fail to exhibit convex curvature and in other cases have an irregular curvature unlike in wild-type mice

• differentiation of fiber cells is disrupted

disorganized lens bow ( J:151538 )

• at P2

cellular

increased lens fiber apoptosis ( J:151538 )

• in the anterior, posterior, and center of the lens