All Phenotypes Tg(THY1-SNCA*A53T)F53Sud MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(THY1-SNCA*A53T)F53Sud
transgene insertion F53, Thomas C Sudhof
MGI:3811331

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(THY1-SNCA*A53T)F53Sud/0	involves: C57BL/6	MGI:3811387

Allelic Composition	Tg(THY1-SNCA*A53T)F53Sud/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(THY1-SNCA*A53T)F53Sud mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:140019 )

• resting tremor initially observed around 8 months of age

hindlimb paralysis ( J:140019 )

• initially observed around 8 months of age

nervous system

increased neuron apoptosis ( J:140019 )

• cell death is seen in spinal cord and is extensive in brain

motor neuron degeneration ( J:140019 )

• results in hindlimb paralysis around 8 months of age

cellular

increased neuron apoptosis ( J:140019 )

• cell death is seen in spinal cord and is extensive in brain

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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