All Phenotypes Bmp4<tm2.1Blh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmp4^tm2.1Blh
targeted mutation 1, Brigid L Hogan
MGI:3811252

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bmp4^tm5.1Bhr/Bmp4^tm2.1Blh	involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster	MGI:4460797
cx2	Bmp4^tm2.1Blh/Bmp4⁺ Slc27a4^pskn/Slc27a4^pskn	involves: 129S6/SvEvTac * FVB/N	MGI:5475249

Allelic Composition	Bmp4^tm5.1Bhr/Bmp4^tm2.1Blh
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm2.1Blh mutation (0 available); any Bmp4 mutation (21 available)
Bmp4^tm5.1Bhr mutation (0 available); any Bmp4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:159629 )

• no live born double mutant heterozygous animal when intecrossed two heterozygous parents

embryo

embryonic growth retardation ( J:159629 )

• at E9.5 resembling the homozygous null phenotype

growth/size/body

embryonic growth retardation ( J:159629 )

• at E9.5 resembling the homozygous null phenotype

Allelic Composition	Bmp4^tm2.1Blh/Bmp4⁺ Slc27a4^pskn/Slc27a4^pskn
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm2.1Blh mutation (0 available); any Bmp4 mutation (21 available)
Slc27a4^pskn mutation (0 available); any Slc27a4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

impaired skin barrier function ( J:194779 )

• by E15.5

decreased hair follicle number ( J:194779 )

• of secondary hair follicles at E16.5

homeostasis/metabolism

impaired skin barrier function ( J:194779 )

• by E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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