Phenotypes associated with this allele

• Allele Symbol: Kat8^tm1.1Avo
• Allele Name: targeted mutation 1.1, Anne K Voss
• Allele ID: MGI:3810976
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat8^tm1.1Avo/Kat8^tm1.1Avo	involves: BALB/cJ * C57BL/6	MGI:3810997

Genotype
MGI:3810997

hm1

• Allelic Composition: Kat8^tm1.1Avo/Kat8^tm1.1Avo
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:139761 )

• although embryos implant they cannot develop beyond the E4.5 blastocyst and die by E5.5

embryo

abnormal inner cell mass apoptosis ( J:139761 )

• apoptosis in the remnant inner cell masses is increased compared to in wild-type

absent inner cell mass proliferation ( J:139761 )

• the inner cell mass fails to proliferate and does not form an inner cell mass outgrowth as do wild-type cells

decreased trophectoderm cell proliferation ( J:139761 )

• in culture, trophectoderm cells from E.5 embryos exhibit limited growth and spreading compared to wild-type cells

cellular

abnormal chromosome morphology ( J:139761 )

• cells exhibit abnormal chromatin distribution that precedes caspase 3 activation

increased mitotic index ( J:139761 )

abnormal inner cell mass apoptosis ( J:139761 )

• apoptosis in the remnant inner cell masses is increased compared to in wild-type

absent inner cell mass proliferation ( J:139761 )

• the inner cell mass fails to proliferate and does not form an inner cell mass outgrowth as do wild-type cells

decreased trophectoderm cell proliferation ( J:139761 )

• in culture, trophectoderm cells from E.5 embryos exhibit limited growth and spreading compared to wild-type cells