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Allele Symbol Allele Name Allele ID |
Tg(THY1-SNCA*A30P)M30Sud transgene insertion M30, Thomas C Sudhof MGI:3810438 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show onset of motoneuron disease at ~9-10 months
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• insoluble alpha-synuclein aggregates form in asymptomatic and symptomatic transgenic mice in terms of neuropathology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive to approximately 14 months
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• resting tremors are detected in mice at about 10 months of age, resulting from motor neuron loss
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• onset of hindlimb mobility problems is observed around 10 months of age due to motor neuron loss
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| N |
• no Lewy body-like pathology is observed in transgenic animals
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• extensive cell death is observed in spinal cord and brain in adult mice
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• loss of motor neurons with age
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• extensive cell death is observed in spinal cord and brain in adult mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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