Phenotypes associated with this allele

• Allele Symbol: Cacng3^tm1Ran
• Allele Name: targeted mutation 1, Roger A Nicoll
• Allele ID: MGI:3810416
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacng3^tm1Ran/Cacng3^tm1Ran	Not Specified	MGI:3810417
cx2	Cacng2^stg/Cacng2^stg Cacng3^tm1Ran/Cacng3^tm1Ran	involves: A/J	MGI:3810418

Genotype
MGI:3810417

hm1

• Allelic Composition: Cacng3^tm1Ran/Cacng3^tm1Ran
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:138791 )

• viable and fertile with normal body weight and nervous system physiology

Genotype
MGI:3810418

cx2

• Allelic Composition: Cacng2^stg/Cacng2^stg; Cacng3^tm1Ran/Cacng3^tm1Ran
• Genetic Background: involves: A/J

mortality/aging

postnatal lethality, incomplete penetrance ( J:138791 )

• most die by 2 weeks of age with few surviving beyond 4 weeks of age

behavior/neurological

ataxia ( J:138791 )

• more severe than in Cacng2^stg single homozygotes

nervous system

abnormal CNS synaptic transmission ( J:138791 )

• the I - V relationship of synaptic AMPA receptor mediated currents is inwardly rectified as opposed to linear as in controls

abnormal excitatory postsynaptic currents ( J:138791 )

• nearly a 90% reduction in compound EPSC is seen

abnormal miniature excitatory postsynaptic currents ( J:138791 )

• Golgi cell mEPSCs show about a 90% reduction in frequency and a large change in amplitude

• decay of mEPSCs is nearly twice as fast as in controls

growth/size/body

decreased body weight ( J:138791 )

• about 55% the weight of control littermates at P14