Phenotypes associated with this allele

• Allele Symbol: Kmt5b^tm1.1Jnw
• Allele Name: targeted mutation 1.1, Thomas Jenuwein
• Allele ID: MGI:3810075
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw	involves: 129 * C57BL/6J	MGI:3810111
cx2	Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw	involves: 129 * C57BL/6J	MGI:3810112

Genotype
MGI:3810111

hm1

• Allelic Composition: Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size of Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw and Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw mice

mortality/aging

neonatal lethality, complete penetrance ( J:139510 )

• mice die within hours of birth probably due to alveolar defects

prenatal lethality, incomplete penetrance ( J:139510 )

• fewer than expected mice are born

growth/size/body

decreased body size ( J:139510 )

• at birth

respiratory system

abnormal pulmonary alveolus morphology ( J:139510 )

• mice die within hours of birth probably due to alveolar defects

Genotype
MGI:3810112

cx2

• Allelic Composition: Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw; Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw
• Genetic Background: involves: 129 * C57BL/6J

Small size of Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw and Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw mice

mortality/aging

neonatal lethality, complete penetrance ( J:139510 )

• mice die within hours of birth probably due to alveolar defects

prenatal lethality, incomplete penetrance ( J:139510 )

• fewer than expected mice are born

cellular

abnormal cell cycle ( J:139510 )

• mouse embryonic fibroblasts exhibit delayed entry into S phase compared to wild-type cells

increased cellular sensitivity to hydroxyurea ( J:139510 )

increased cellular sensitivity to ultraviolet irradiation ( J:139510 )

decreased fibroblast proliferation ( J:139510 )

• mouse embryonic fibroblasts exhibit reduced proliferation and reach plateau sooner compared to wild-type cells

early cellular replicative senescence ( J:139510 )

• mouse embryonic fibroblasts cease replicating sooner than in wild-type cells

abnormal DNA repair ( J:139510 )

• mouse embryonic fibroblasts exhibit increased accumulation of DNA damage following treatment with gamma radiation compared to in similarly treated wild-type cells

• however, the DNA of mouse embryonic fibroblasts exhibit normal sensitivity to DNA damage

growth/size/body

decreased body size ( J:139510 )

• at birth

respiratory system

abnormal pulmonary alveolus morphology ( J:139510 )

• mice die within hours of birth probably due to alveolar defects

homeostasis/metabolism

abnormal DNA repair ( J:139510 )

• mouse embryonic fibroblasts exhibit increased accumulation of DNA damage following treatment with gamma radiation compared to in similarly treated wild-type cells

• however, the DNA of mouse embryonic fibroblasts exhibit normal sensitivity to DNA damage