All Phenotypes Kmt5b<tm1Jnw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kmt5b^tm1Jnw
targeted mutation 1, Thomas Jenuwein
MGI:3810074

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kmt5b^tm1Jnw/Kmt5b^tm1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca	MGI:3810116

Allelic Composition	Kmt5b^tm1Jnw/Kmt5b^tm1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Kmt5b^tm1Jnw mutation (0 available); any Kmt5b mutation (42 available)
Kmt5c^tm1.1Jnw mutation (0 available); any Kmt5c mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:139510 )

N	• V(D)J recombination in B and T cells is normal

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

• however, there is no increase in Igh chromosomal aberrations

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal

hematopoietic system

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

• however, there is no increase in Igh chromosomal aberrations

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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