All Phenotypes Stx1a<tm2.1Sud> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stx1a^tm2.1Sud
targeted mutation 2.1, Thomas C Sudhof
MGI:3809921

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stx1a^tm2.1Sud/Stx1a^tm2.1Sud	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3832396
cx2	Stx1a^tm2.1Sud/Stx1a^tm2.1Sud Stx1b^tm1.1Sud/Stx1b^tm1.1Sud	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3832394

Allelic Composition	Stx1a^tm2.1Sud/Stx1a^tm2.1Sud
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx1a^tm2.1Sud mutation (0 available); any Stx1a mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:138035 )

N	• homozygotes show no decrease in survival or other obvious phenotypes

Allelic Composition	Stx1a^tm2.1Sud/Stx1a^tm2.1Sud Stx1b^tm1.1Sud/Stx1b^tm1.1Sud
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx1a^tm2.1Sud mutation (0 available); any Stx1a mutation (25 available)
Stx1b^tm1.1Sud mutation (1 available); any Stx1b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:138035 )

• a 20% increase in size of the postsynaptic density is observed compared to cultured cortical neurons with wild type Stx1a

abnormal synaptic vesicle recycling ( J:138035 )

• about a 25% increase in synaptic vesicle docking at synapses in cultured cortical neurons compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23