About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dlx6tm1Jlr
targeted mutation 1, John Rubenstein
MGI:3809858
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dlx6tm1Jlr/Dlx6tm1Jlr Not Specified MGI:3809892
cx2
 		Dlx1tm1Jlr/Dlx1tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr 		involves: 129X1/SvJ MGI:3809893
cx3
 		Dlx2tm1Jlr/Dlx2tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr 		involves: 129X1/SvJ MGI:3809894


Genotype
MGI:3809892
hm1
Allelic
Composition		 Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx6tm1Jlr mutation (1 available); any Dlx6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:139700 )
• mice die within a day of birth due to aerophagia

craniofacial
craniofacial phenotype ( J:139700 )
N
• unlike in Dlx6/Dlx5tm1Tlu homozygotes, the nasal and otic capsule are normal
mandibular condyloid process hypoplasia ( J:139700 )
• the mandibular condylar process is hypoplastic
absent mandibular coronoid process ( J:139700 )
• the dentary lacks the coronoid process
small mandible ( J:139700 )
• the mandible is slightly reduced such that the dentary lacks the coronoid process and has a hypoplastic condylar process
abnormal gonial bone morphology ( J:139700 )
• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis

hearing/vestibular/ear
abnormal gonial bone morphology ( J:139700 )
• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis
decreased tympanic ring size ( J:139700 )
• the ectotympanic of the ear is shortened

skeleton
mandibular condyloid process hypoplasia ( J:139700 )
• the mandibular condylar process is hypoplastic
absent mandibular coronoid process ( J:139700 )
• the dentary lacks the coronoid process
small mandible ( J:139700 )
• the mandible is slightly reduced such that the dentary lacks the coronoid process and has a hypoplastic condylar process
abnormal gonial bone morphology ( J:139700 )
• the gonial bone is attached to an ectopic piece (named os paradoxicum) of bone extending towards the ala temporalis

digestive/alimentary system
aerophagia ( J:139700 )
• mice die within a day of birth due to aerophagia




Genotype
MGI:3809893
cx2
Allelic
Composition		 Dlx1tm1Jlr/Dlx1tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx1tm1Jlr mutation (1 available); any Dlx1 mutation (21 available)
Dlx6tm1Jlr mutation (1 available); any Dlx6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn of the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid

hearing/vestibular/ear
absent tympanic ring ( J:139700 )
• the ectotympanic is reduced or lost
decreased tympanic ring size ( J:139700 )
• the ectotympanic is reduced or lost

skeleton
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn of the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid




Genotype
MGI:3809894
cx3
Allelic
Composition		 Dlx2tm1Jlr/Dlx2tm1Jlr
Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx2tm1Jlr mutation (1 available); any Dlx2 mutation (25 available)
Dlx6tm1Jlr mutation (1 available); any Dlx6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn or the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid

hearing/vestibular/ear
absent tympanic ring ( J:139700 )
• the ectotympanic is reduced or lost
decreased tympanic ring size ( J:139700 )
• the ectotympanic is reduced or lost

skeleton
abnormal cranium morphology ( J:139700 )
• the ventrolateral side of the skull exhibits a duplicate lamina obturans beside the endogenous one
abnormal pterygoid bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal hyoid bone morphology ( J:139700 )
• mice exhibit an abnormal basihyoid and lesser horn or the hyoid
abnormal mandible morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid
abnormal zygomatic bone morphology ( J:139700 )
• unlike in wild-type mice, dentaries are shortened, fragmented and bifurcated to become bones resembling the maxilla, jugal and pterygoid




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory