Phenotypes associated with this allele

• Allele Symbol: Grm7^tm1Betz
• Allele Name: targeted mutation 1, Heinrich Betz
• Allele ID: MGI:3809761
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm7^tm1Betz/Grm7^tm1Betz	B6.129P2-Grm7^tm1Betz	MGI:3809762

Genotype
MGI:3809762

hm1

• Allelic Composition: Grm7^tm1Betz/Grm7^tm1Betz
• Genetic Background: B6.129P2-Grm7^tm1Betz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:138831 )

• increased sensitivity to pentylenetetrazol induced seizures and mortality

nervous system

nervous system phenotype ( J:138831 )

N • despite expression patterns, no obvious morphological abnormalities are seen in the cortex, hippocampus, or cerebellum

increased susceptibility to pharmacologically induced seizures ( J:138831 )

• increased sensitivity to pentylenetetrazol induced seizures and mortality

abnormal excitatory postsynaptic currents ( J:138831 )

• spontaneous EPSCs in cultured cerebellar neurons are insensitive to inhibition by 400 um L-AP-4 and GF109203X unlike in wild-type cells

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:138831 )

• increased sensitivity to pentylenetetrazol induced seizures and mortality

abnormal spatial working memory ( J:138831 )

• fail to show improvement in working memory error rates in an eight-arm radial maze

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:138831 )

• increased sensitivity to pentylenetetrazol induced seizures and mortality