Analysis Tools
reproductive system
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• female mice heterozygous for this mutation are poor breeders
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Allele Symbol Allele Name Allele ID |
Ikbkgm1Btlr mutation 1, Bruce Beutler MGI:3808877 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female mice heterozygous for this mutation are poor breeders
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• despite earlier reports that hemizygous males are born at a lower-than-expected frequency, larger numbers of births showed that hemizygotes are born at the expected Mendelian ratio; they survive for at least 4-6 weeks
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N |
• type 1 interferon (IFN) production by macrophages from hemizygous mutant male mice in response to the toll-like receptor (TLR) 3 ligand poly I:C (a dsRNA mimetic) and to dsDNA is normal
• mutant mice have normal CD8+ lymphocyte function
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• mutant mice have a two-fold reduction in peripheral CD4+CD25+ lymphocytes (regulatory T cells)
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• upon stimulation with the TLR4 ligand, lipopolysaccharide (LPS), peritoneal macrophages from hemizygous mutant male mice exhibit a subtly reduced TNF-alpha response compared to that of wild-type mice
• mutant macrophages produce normal amounts of tumor necrosis factor (TNF) alpha in response to stimulation with all other toll-like receptor (TLR) ligands tested: the TLR3 ligand poly(I:C); the TLR1/2 ligand Pam3CSK4; the TLR7 ligand resiquimod; the TLR9 ligand CpG ODN; and the TLR6 ligands peptidoglycan and MALP-2
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• mutant mice have a two-fold reduction in peripheral CD4+CD25+ lymphocytes (regulatory T cells)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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