All Phenotypes Fen1<tm3Klng> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fen1^tm3Klng
targeted mutation 3, Arne Klungland
MGI:3808783

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fen1^tm3Klng/Fen1^tm3Klng	involves: 129X1/SvJ * C57BL/6	MGI:3808847

Allelic Composition	Fen1^tm3Klng/Fen1^tm3Klng
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fen1^tm3Klng mutation (0 available); any Fen1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die around E12.5

embryo

abnormal embryo development ( J:138901 )

• embryos are pale and fail to change from a U-shaped inverted blastoderm to a C-shaped body by E9.5

• embryos exhibit increased apoptosis at E12.5

embryonic growth retardation ( J:138901 )

• at E10.5

decreased embryo size ( J:138901 )

• at E10.5

open neural tube ( J:138901 )

cellular

abnormal cell physiology ( J:138901 )

• embryonic cells cannot be used to establish embryonic fibroblast cell lines

growth/size/body

embryonic growth retardation ( J:138901 )

• at E10.5

decreased embryo size ( J:138901 )

• at E10.5

nervous system

open neural tube ( J:138901 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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