Phenotypes associated with this allele

• Allele Symbol: Fen1^tm2Klng
• Allele Name: targeted mutation 2, Arne Klungland
• Allele ID: MGI:3808779
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fen1^tm2Klng/Fen1^tm2Klng	involves: 129X1/SvJ * C57BL/6	MGI:3808846

Genotype
MGI:3808846

hm1

• Allelic Composition: Fen1^tm2Klng/Fen1^tm2Klng
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:138901 )

N • mice exhibit normal hypermutation and class-switch recombination of immunoglobin genes

enlarged spleen ( J:138901 )

• female mice develop enlarged spleens due to multifocal white areas not observed in wild-type mice

abnormal spleen B cell follicle morphology ( J:138901 )

♀ • female mice exhibit enlarged and more numerous follicles compared to in wild-type mice

increased spleen B cell follicle number ( J:138901 )

♀

increased spleen B cell follicle size ( J:138901 )

♀

abnormal spleen marginal zone morphology ( J:138901 )

• enlarged in female mice

lymphoid hyperplasia ( J:138901 )

• female mice exhibit enlargement or focal changes in the lungs, liver, kidney, mesenteric lymph nodes and thymus not observed in wild-type mice

• both female and male mice exhibit lymphoid hyperplasia

respiratory system

increased lung adenoma incidence ( J:138901 )

• female mice exhibit an increase in epithelial hyperplasia, adenomas and adenocarcinomas of the lung compared to in wild-type mice

neoplasm

increased lung adenoma incidence ( J:138901 )

• female mice exhibit an increase in epithelial hyperplasia, adenomas and adenocarcinomas of the lung compared to in wild-type mice

increased B cell derived lymphoma incidence ( J:138901 )

• female mice exhibit an increase in follicular lymphoma and diffuse large-B cell lymphoma of the centroblastic type in the spleen compared to in wild-type mice

• however, marginal zone distinctions are not lost

• metastases are noted in the lungs, liver and kidneys of female mice unlike in wild-type mice

increased sarcoma incidence ( J:138901 )

• one female mouse developed histiocytic sarcoma

adipose tissue

increased white adipose tissue amount ( J:138901 )

• in the subcutis, retroperitoneum, abdomen, mediastinum and around the epididymes

increased fat cell size ( J:138901 )

• white adipocytes exhibit minimal or mild hypertrophy

growth/size/body

obese ( J:138901 )

• mice develop non-diabetic obesity by 9 months of age

enlarged spleen ( J:138901 )

• female mice develop enlarged spleens due to multifocal white areas not observed in wild-type mice

cellular

decreased cell proliferation ( J:138901 )

• mouse embryonic fibroblasts (MEFs) exhibit reduced cellular proliferation compared to wild-type MEFs especially at low densities

hematopoietic system

enlarged spleen ( J:138901 )

• female mice develop enlarged spleens due to multifocal white areas not observed in wild-type mice

abnormal spleen B cell follicle morphology ( J:138901 )

♀ • female mice exhibit enlarged and more numerous follicles compared to in wild-type mice

increased spleen B cell follicle number ( J:138901 )

♀

increased spleen B cell follicle size ( J:138901 )

♀

abnormal spleen marginal zone morphology ( J:138901 )

• enlarged in female mice