Phenotypes associated with this allele

• Allele Symbol: Pofut1^tm1.1Ysa
• Allele Name: targeted mutation 1.1, Yumiko Saga
• Allele ID: MGI:3808705
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pofut1^tm1.1Ysa/Pofut1^tm1.1Ysa	involves: C57BL/6 * CBA * SJL	MGI:3808713
cn2	Pofut1^tm1Ysa/Pofut1^tm1.1Ysa Tg(Amh-cre)#Ysa/0	involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj	MGI:5426708
cn3	Nanos3^tm2.1(cre)Ysa/Nanos3^+ Pofut1^tm1Ysa/Pofut1^tm1.1Ysa	involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj	MGI:5426709

Genotype
MGI:3808713

hm1

• Allelic Composition: Pofut1^tm1.1Ysa/Pofut1^tm1.1Ysa
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:139209 )

• mice die at E10

cardiovascular system

abnormal blood vessel morphology ( J:139209 )

abnormal cardiac epithelial to mesenchymal transition ( J:139209 )

abnormal heart morphology ( J:139209 )

abnormal heart development ( J:139209 )

• heart development is severely affected during valve formation due to a lack of mesenchyme cells

embryo

embryonic growth retardation ( J:139209 )

• at E9.5

abnormal neural tube morphology ( J:139209 )

abnormal somite development ( J:139209 )

nervous system

abnormal neural tube morphology ( J:139209 )

growth/size/body

embryonic growth retardation ( J:139209 )

• at E9.5

Genotype
MGI:5426708

cn2

• Allelic Composition: Pofut1^tm1Ysa/Pofut1^tm1.1Ysa; Tg(Amh-cre)#Ysa/0
• Genetic Background: involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj

mortality/aging

prenatal lethality ( J:183324 )

• mice are not born at expected Mendelian frequency

reproductive system

reproductive system phenotype ( J:183324 )

N • 8-week old mutant males produce normal litter sizes, have comparable testis size, as well as similar histology of the testis and epididymis to controls; similarly, 4-month old males generate normal litter size and have comparable testes histologically to control males

Genotype
MGI:5426709

cn3

• Allelic Composition: Nanos3^{tm2.1(cre)Ysa}/Nanos3⁺; Pofut1^tm1Ysa/Pofut1^tm1.1Ysa
• Genetic Background: involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj

reproductive system

reproductive system phenotype ( J:183324 )

N • in 8-week old males, external morphology of the testes, histology of seminiferous tubules, and number of sperm in epididymides are normal; when bred to wild-type females, fecundity is similar to controls