Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1tm2(cre)Ysa mutation
(1 available);
any
Mesp1 mutation
(17 available)
Pofut1tm1Ysa mutation
(0 available);
any
Pofut1 mutation
(22 available)
Tg(CAG-cat,-Notch1)1Ysa mutation
(1 available)
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cardiovascular system
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• trabecular layer defects observed in Pofut1tm1Ysa/Pofut1tm1Ysa Mesp1tm2(cre)Ysa/Mesp1+ mice are partially rescued
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growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pofut1tm1.1Ysa mutation
(0 available);
any
Pofut1 mutation
(22 available)
Pofut1tm1Ysa mutation
(0 available);
any
Pofut1 mutation
(22 available)
Tg(Amh-cre)#Ysa mutation
(0 available)
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mortality/aging
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• mice are not born at expected Mendelian frequency
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reproductive system
N |
• 8-week old mutant males produce normal litter sizes, have comparable testis size, as well as similar histology of the testis and epididymis to controls; similarly, 4-month old males generate normal litter size and have comparable testes histologically to control males
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos3tm2.1(cre)Ysa mutation
(1 available);
any
Nanos3 mutation
(28 available)
Pofut1tm1.1Ysa mutation
(0 available);
any
Pofut1 mutation
(22 available)
Pofut1tm1Ysa mutation
(0 available);
any
Pofut1 mutation
(22 available)
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reproductive system
N |
• in 8-week old males, external morphology of the testes, histology of seminiferous tubules, and number of sperm in epididymides are normal; when bred to wild-type females, fecundity is similar to controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1tm2(cre)Ysa mutation
(1 available);
any
Mesp1 mutation
(17 available)
Pofut1tm1Ysa mutation
(0 available);
any
Pofut1 mutation
(22 available)
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mortality/aging
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• mice survive a little longer than knockout mice
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cardiovascular system
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• trabecular layers are underdeveloped
• endocardial layers are abnormally detached from myocardial layers
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• valve formation is abnormal due to a lack of epithelial-mesenchymal transition and defective trabeculae
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muscle
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• trabecular layers are underdeveloped
• endocardial layers are abnormally detached from myocardial layers
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