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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Plp1-Nfasc*)1Brp
transgene insertion 1, Peter J Brophy
MGI:3808610
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
B6.Cg-Nfasctm1.1Brp Tg(Plp1-Nfasc*)1Brp MGI:3808612
cx2
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3808699


Genotype
MGI:3808612
cx1
Allelic
Composition
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
Genetic
Background
B6.Cg-Nfasctm1.1Brp Tg(Plp1-Nfasc*)1Brp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasctm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Plp1-Nfasc*)1Brp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• despite the re-establishment of paranodal junctional complexes, the node complex is not rescued




Genotype
MGI:3808699
cx2
Allelic
Composition
Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasctm1.1Brp mutation (0 available); any Nfasc mutation (61 available)
Tg(Plp1-Nfasc*)1Brp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal interheminodal gaps, oligodendrocyte process migration and localization of sodium channels to the nodes in the central nervous system





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory