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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Plp1-Nfasc*)1Brp
transgene insertion 1, Peter J Brophy
MGI:3808610
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0 		B6.Cg-Nfasctm1.1Brp Tg(Plp1-Nfasc*)1Brp MGI:3808612
cx2
 		Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3808699


Genotype
MGI:3808612
cx1
Allelic
Composition		 Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
Genetic
Background		 B6.Cg-Nfasctm1.1Brp Tg(Plp1-Nfasc*)1Brp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasctm1.1Brp mutation (0 available); any Nfasc mutation (59 available)
Tg(Plp1-Nfasc*)1Brp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal sciatic nerve morphology ( J:107591 )
• despite the re-establishment of paranodal junctional complexes, the node complex is not rescued




Genotype
MGI:3808699
cx2
Allelic
Composition		 Nfasctm1.1Brp/Nfasctm1.1Brp
Tg(Plp1-Nfasc*)1Brp/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasctm1.1Brp mutation (0 available); any Nfasc mutation (59 available)
Tg(Plp1-Nfasc*)1Brp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:139185 )
N
• mice exhibit normal interheminodal gaps, oligodendrocyte process migration and localization of sodium channels to the nodes in the central nervous system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory