All Phenotypes Orm2<tm1(KOMP)Vlcg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Orm2^{tm1(KOMP)Vlcg}
targeted mutation 1, Velocigene
MGI:3808483

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orm2^{tm1(KOMP)Vlcg}/Orm2^{tm1(KOMP)Vlcg}	C57BL/6N-Orm2^{tm1(KOMP)Vlcg}/Mmucd	MGI:6478810

Allelic Composition	Orm2^{tm1(KOMP)Vlcg}/Orm2^{tm1(KOMP)Vlcg}
Genetic Background	C57BL/6N-Orm2^{tm1(KOMP)Vlcg}/Mmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orm2^{tm1(KOMP)Vlcg} mutation (1 available); any Orm2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney inflammation ( J:292194 )

• mice show exacerbated renal inflammation and macrophage infiltration after unilateral ureteral obstruction compared to wild-type mice

renal fibrosis ( J:292194 )

• mice show exacerbated renal fibrosis after unilateral ureteral obstruction compared to wild-type mice

• treatment with Am80, a synthetic retinoic acid receptor agonist, has no effect on unilateral ureteral obstruction-induced renal fibrosis

• treatment with all-trans retinoic acid has a partial anti-fibrotic effect on unilateral ureteral obstruction-induced renal fibrosis

immune system

kidney inflammation ( J:292194 )

• mice show exacerbated renal inflammation and macrophage infiltration after unilateral ureteral obstruction compared to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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