All Phenotypes Cs<ahl4> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cs^ahl4
age related hearing loss 4
MGI:3807581

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cs^ahl4/Cs^ahl4	A/J	MGI:3807675
hm2	Cs^ahl4/Cs^ahl4	(A/J x B6.A-Cs^ahl4)F1	MGI:6121361
hm3	Cs^ahl4/Cs^ahl4	C57BL/6J-Chr 10^A/J/NaJ	MGI:3807711
cx4	Cs^ahl4/Cs^ahl4 mt-Tr^m1/mt-Tr^m1	involves: A/J * C57BL/6J	MGI:6121364

Allelic Composition	Cs^ahl4/Cs^ahl4
Genetic Background	A/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cs^ahl4 mutation (4 available); any Cs mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:139222 )

• in A/J mice ABR thresholds at 16 and 32 kHz are elevated by 25 days of age and by 3 months of age the ABR thresholds are more than 50 dB above normal

increased susceptibility to age-related hearing loss ( J:139222 )

• in A/J mice onset of hearing loss is found as early as 25 days of age and is much more severe at 6 months of age than that found in C57BL/6J

impaired hearing ( J:139222 )

Allelic Composition	Cs^ahl4/Cs^ahl4
Genetic Background	(A/J x B6.A-Cs^ahl4)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cs^ahl4 mutation (4 available); any Cs mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:188196 )

• compared with the reciprocal F1 cross at 6 and 9 months

Allelic Composition	Cs^ahl4/Cs^ahl4
Genetic Background	C57BL/6J-Chr 10^A/J/NaJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cs^ahl4 mutation (4 available); any Cs mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:139222 , J:188196 )

• relative to C57BL/6J controls, C57BL/6J-Chr 10/NaJ consomic mice have ABR thresholds only slightly higher at 3 months of age, but 30 dB higher at 6 months of age and 50 dB higher at 9 months of age (J:139222)

increased susceptibility to age-related hearing loss ( J:139222 )

• the onset of hearing loss occurs earlier and progresses more rapidly than in C57BL/6J

impaired hearing ( J:139222 )

• 16 kHz ABR thresholds average 30 dB higher than in C57BL/6J controls

Allelic Composition	Cs^ahl4/Cs^ahl4 mt-Tr^m1/mt-Tr^m1
Genetic Background	involves: A/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cs^ahl4 mutation (4 available); any Cs mutation (34 available)
mt-Tr^m1 mutation (6 available); any mt-Tr mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:188196 )

• compared with Cs^ahl4 homozygotes with mitochondria originating from C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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