All Phenotypes E2f3<tm3.1Gle> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

E2f3^tm3.1Gle
targeted mutation 3.1, Gustavo Leone
MGI:3806817

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	E2f3^tm3.1Gle/E2f3^tm3.1Gle	FVB.129S6-E2f3^tm3.1Gle	MGI:3806836
cx2	E2f1^tm1Meg/E2f1^tm1Meg E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm3.1Gle/E2f3^tm3.1Gle	involves: 129 * FVB/N * NIH Black Swiss	MGI:3806840
cx3	E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm3.1Gle/E2f3^tm3.1Gle	involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss	MGI:3806845
cx4	E2f1^tm1Meg/E2f1^tm1Meg E2f3^tm3.1Gle/E2f3^tm3.1Gle	involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss	MGI:3806846

Allelic Composition	E2f3^tm3.1Gle/E2f3^tm3.1Gle
Genetic Background	FVB.129S6-E2f3^tm3.1Gle

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3^tm3.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:138289 )

N	• unlike mice lacking both isoforms, in mice lacking only the E2f3a isoform no significant embryonic lethality is seen

Allelic Composition	E2f1^tm1Meg/E2f1^tm1Meg E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm3.1Gle/E2f3^tm3.1Gle
Genetic Background	involves: 129 * FVB/N * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1^tm1Meg mutation (2 available); any E2f1 mutation (25 available)
E2f2^tm1Zubi mutation (1 available); any E2f2 mutation (29 available)
E2f3^tm3.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:138289 )

N	• unlike triple mutant mice lacking expression of the E2f3a isoform, triple mutant mice lacking the E2f3b isoform survive to adulthood

cellular

decreased cell proliferation ( J:138289 )

• in MEFs after 5 and 6 days in culture compared to littermate-derived controls

growth/size/body

decreased body weight ( J:138289 )

Allelic Composition	E2f2^tm1Zubi/E2f2^tm1Zubi E2f3^tm3.1Gle/E2f3^tm3.1Gle
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f2^tm1Zubi mutation (1 available); any E2f2 mutation (29 available)
E2f3^tm3.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:138289 )

• develop normally and have a normal lifespan

Allelic Composition	E2f1^tm1Meg/E2f1^tm1Meg E2f3^tm3.1Gle/E2f3^tm3.1Gle
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1^tm1Meg mutation (2 available); any E2f1 mutation (25 available)
E2f3^tm3.1Gle mutation (0 available); any E2f3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:138289 )

• young mice are slightly but significantly smaller

• but by 90 days of age no significant difference in weight is detected

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