Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl2tm1.1Pado mutation
(0 available);
any
Rtn4rl2 mutation
(24 available)
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nervous system
N |
• inhibition of neurite outgrowth following treatment with trisialoganglioside (GT1b) antibodies or soluble MAG is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl1tm1.1Rojg mutation
(0 available);
any
Rtn4rl1 mutation
(25 available)
Rtn4rl2tm1.1Pado mutation
(0 available);
any
Rtn4rl2 mutation
(24 available)
Rtn4rtm1.1Pado mutation
(0 available);
any
Rtn4r mutation
(24 available)
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nervous system
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• modestly improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush
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• cerebellar granule neurons experience significant but incomplete release of growth inhibition in culture
• strong inhibition of neuron growth when challenged with high concentrations of chondroitin sulfate proteoglycans
• neurites are significantly longer than those of any controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl2tm1.1Pado mutation
(0 available);
any
Rtn4rl2 mutation
(24 available)
Rtn4rtm1.1Pado mutation
(0 available);
any
Rtn4r mutation
(24 available)
|
|
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nervous system
N |
• no improvement relative to controls in recovery of retinal ganglion cell axons from retro-orbital optic nerve crush
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