Phenotypes associated with this allele

• Allele Symbol: Tg(H2-K-HLA-G,B2M)1Alm
• Allele Name: transgene insertion 1, Andrew L Mellor
• Allele ID: MGI:3806366
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(H2-K-HLA-G,B2M)1Alm/0	CBA/Ca-Tg(H2-K-HLA-G,B2M)1Alm/CmwJ	MGI:3844468

Genotype
MGI:3844468

tg1

• Allelic Composition: Tg(H2-K-HLA-G,B2M)1Alm/0
• Genetic Background: CBA/Ca-Tg(H2-K-HLA-G,B2M)1Alm/CmwJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:140016 )

• T cell proliferation in response to human xenoantigens is greater than in wild-type mice

abnormal cytotoxic T cell physiology ( J:140016 )

• a cytotoxic T cell response is elicited when mice are immunized with a peptide that binds specifically to HLA-G molecules unlike in similarly treated wild-type cell

hematopoietic system

increased T cell proliferation ( J:140016 )

• T cell proliferation in response to human xenoantigens is greater than in wild-type mice

abnormal cytotoxic T cell physiology ( J:140016 )

• a cytotoxic T cell response is elicited when mice are immunized with a peptide that binds specifically to HLA-G molecules unlike in similarly treated wild-type cell

cellular

increased T cell proliferation ( J:140016 )

• T cell proliferation in response to human xenoantigens is greater than in wild-type mice