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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sytl1tm1Mitf
targeted mutation 1, Mitsunori Fukuda
MGI:3805583
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sytl1tm1Mitf/Sytl1tm1Mitf involves: 129P2/OlaHsd MGI:3805678


Genotype
MGI:3805678
hm1
Allelic
Composition		 Sytl1tm1Mitf/Sytl1tm1Mitf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sytl1tm1Mitf mutation (1 available); any Sytl1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
pancreatic acinar cell zymogen granule accumulation ( J:138210 )
• the number of acinar zygomen granules in fasted mice is doubled compared to in wild-type mice due to reduced exocytosis

endocrine/exocrine glands
pancreatic acinar cell zymogen granule accumulation ( J:138210 )
• the number of acinar zygomen granules in fasted mice is doubled compared to in wild-type mice due to reduced exocytosis
abnormal pancreas secretion ( J:138210 )
• treatment of mice with a strong stimuli that mimics the fed state causes increased amylase secretion due to release of the increased number of acinar zygomen granules that accumulate in the fasted state




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory