Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-FIGF)2Ali
• Allele Name: transgene insertion 2, Kari Alitalo
• Allele ID: MGI:3805117
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Vegfc^tm1Ali/Vegfc^+ Tg(KRT14-FIGF)2Ali/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3805314
tg2	Tg(KRT14-FIGF)2Ali/0	involves: FVB/N	MGI:3805315

Genotype
MGI:3805314

cx1

• Allelic Composition: Vegfc^tm1Ali/Vegfc⁺; Tg(KRT14-FIGF)2Ali/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

lymphatic vessel hyperplasia ( J:137909 )

• hyperplastic cutaneous lymphatic vasculature

• hyperplasia is not as strong as in transgenic mice wild-type for Vegfc

Genotype
MGI:3805315

tg2

• Allelic Composition: Tg(KRT14-FIGF)2Ali/0
• Genetic Background: involves: FVB/N

immune system

lymphatic vessel hyperplasia ( J:68138 , J:137909 )

• enlarged lymphatic vessels in the skin often in proximity to the hair follicles (J:68138)

• diameter of lymphatic capillaries is increased about 3-fold but vessels do not appear leaky (J:68138)

• hyperplastic cutaneous lymphatic vasculature (J:137909)

cardiovascular system

cardiovascular system phenotype ( J:68138 )

N • despite abnormalities in the lymphatic vasculature, blood vessels appear normal